Neurology

by

May the slope of your pain function always be negative

I’ve been thinking about something I wrote in my blog post yesterday.  I had thrown out the thought, in passing, about how it seemed as though all the things in my life that I still do are not things I necessarily do for joy or out of desire to achieve some goal, but rather they are things which are more painful not to do than to do, and so I do them.

There isn’t really a positive motivation—not the pursuit of happiness or improvement or fulfillment or enrichment.  It’s just that the feeling of stress and tension and anxiety (or whatever) regarding the prospect of, for instance, not going to work rapidly becomes worse than the equivalent feelings about going to work.

That’s not a great state of affairs.  Don’t get me wrong; it’s entirely natural.  I’ve written about this many times, this recognition of the fact that the negative experiences—fear, pain, revulsion, disgust, and so on—are the biologically most important ones.  Creatures that don’t run from danger, that don’t avoid injury, that don’t shy away from potential infection and poison, are far less likely to survive to reproduce than creatures that do those things.

We see clinical examples of people lacking some of these faculties—such as those with congenital insensitivity to pain—and while we might envy them a life without agony, it tends to be quite a short life.  Also, they tend to become immobile and deformed due to damage they do to their joints by not shifting position to improve blood flow.

In case you didn’t know, that’s one of the reasons you can’t stand completely still for very long; it’s not good for you.

But many of us, especially in the modern world, have some things that we do for positive experience.  Some of them are dubious, but food, sex, companionship/conversation, singing, dancing, all that stuff, are positive things.  Unfortunately, positive experience cannot be allowed—by biology—to last too long.

As Yuval Harari noted, a squirrel that got truly lasting satisfaction from eating a nut would be a squirrel that lived a very short—albeit fairly happy—life, and would be unlikely to leave too many offspring.

Maybe this is what happens to some drug addicts.  Maybe they really do get satisfaction or at least pleasure from drugs—and maybe that is what ends up destroying them.  At some level, that’s not truly in question, is it?  People who are addicted to drugs forego other pleasures and other positive things, but perhaps more importantly, they fail to avoid many sources of pain and fear and injury.

The reality is probably a bit of an amalgam, I suppose.  I would not say it’s a quantum superposition, though, except in the sense that everything is a quantum superposition (or, rather, a whole bunch of them).

This is one situation in which I think I’m right and Roger Penrose is wrong—a bold claim, but I think a fair one—in that I see no reason to suspect that the nature of consciousness either requires or even allows quantum processes, other than in the trivial sense that everything* involves quantum processes.  But there’s no reason seriously to think that (for instance) neurotubules can even sustain a quantum superposition internally, let alone that such a process can somehow affect the other processes of the neuron, many of which are well understood and show no sign of input from weird states of neurotubules, which act mainly structurally in neurons.

If deep learning systems—LLMs and the like—have demonstrated anything, it’s that intuitive thought** does not require anything magical, but rather can be a product of carefully curated, pruned, and adjusted networks of individual data processing units, feeding backward and forward and sideways in specific (but not necessarily preplanned or even well understood) ways.  No quantum magic or neurological voodoo need be involved.

I think too many people, even really smart people like Penrose, really want human intelligence to be something “special”, to be something that cannot be achieved except within human heads, and maybe in the heads of similar creatures.  Surely (they seem to believe) the human mind must have some pseudo-divine spark.  Otherwise, we oh-so-clever humans are just…just creatures in the world, evolved organisms, mortal and evanescent like everyone and everything else.

Which, of course, all the evidence and reasoning seems to suggest is the case.

Maybe, deep down, there isn’t much more to life than trying to choose the path from moment to moment that steers you toward the least “painful” thing you can find.

Please note, I’m not speaking here about some metaphorical continuum, some number line that points toward pleasure in one direction and pain in the other.  That’s at best a toy model.  In the actual body, in the actual nervous system, pain and fear and pleasure and motivation are literally separate systems, though clearly they interact.  Pleasure is not merely the absence of pain, nor is pain merely the absence of pleasure.  Even peripherally, the nerves that carry painful sensations (which include itching, as I noted yesterday!) use different paths and different neurotransmitters than the ones that deal in pleasure and positive sensation.

Within the brain, the amygdala and the nucleus accumbens (for instances) are separate structures—and more importantly, they perform different functions.  There’s nothing magical about their locations in the brain or the particular neurotransmitters they use.  Those things are accidents of evolutionary past.

There’s nothing inherently stimulating about epinephrine, and there’s nothing inherently soothing about endorphins or oxytocin, and there’s nothing inherently motivating or joyful about dopamine and serotonin.  They are all just molecular keys that have been forged to open specific “locks” or activate (or inactivate) specific processes in parts of other nerve cells (and some other types of cells).  It’s the process that does the work, Neo, not the neurotransmitter.

This brings up a slight pet peeve I have about people discussing “dopamine seeking” (often when talking about ADHD).  I know, the professionals probably use this as a mere shorthand, but that can be misleading to the relatively numerous nonprofessionals in the world.  The brain is not just a chemical vat.  Depression and the like are not just “chemical imbalances” in some ongoing multi-level redux reaction or something, they are malfunctions of complicated processes.  Improving them should be at least as involved as training an AI to recognize cat faces, wouldn’t you think?

But one can do the latter without really knowing the specifics of what is going on in the system.  It’s just sometimes difficult, and the things you think you need to train toward or with often end up giving you what you didn’t really want, or at least what you didn’t expect.

Maybe this is part of why mindfulness is useful (it’s not the only part).  With mindfulness, one actually engages in internal monitoring, not so much of the mechanical processes happening—no amount of mere meditation can reveal the structure of a neuron—but of the higher-scale, “emergent” processes happening, and one can learn from them and be better aware.  This can be an end in and of itself, of course.  But it can also at least sometimes help people decrease the amount of suffering they experience in their lives.

Speaking of that, I hope that reading this post has been at least slightly less painful for you than not reading it would have been.  Writing it has been less painful than I imagine not writing it would have been.  That doesn’t help my other chronic pain, of course, which continues to act up.

*With the possible exception of gravity.

**I.e., nonlinear processing and pattern recognition, the kind many people including Penrose think cannot be explained by ordinary computation, a la Gödel’s Incompleteness Theorem, etc.

 

by

Happy Valentine’s Day, you filthy animals.

Well, guess what.  It’s Saturday now, and I’m writing a blog post, which can only mean that I am working today.  At the last minute, the schedule of the office was changed and now we’re working.  And we’re supposedly going to be doing this now every other (meaning alternating ones) Saturday.  But, of course, I worked last Saturday.  And who knows how things will change in the future?  I’m pretty sure not even the boss knows, because he changes the specifics somewhat irregularly, though there are always colorably reasonable purposes behind such changes.

I suppose I could merely have said, “No, I’m not coming in this weekend.  I worked last weekend, I had to walk to the bank after work and I caused my knees and my pain in general to flare up badly, and that problem continues.  I need a fucking break.”  But, of course, I’m not really built quite that way.  I have been too strongly trained to operate on the approach that to shirk going to work is to be a jerk*.

So, here I am, at the office, and it’s the middle of the night.  That’s right, when it got to be time to leave, I was in too much pain to want to ride the train‒it’s not comfortable to sit in, and I usually have to go to the upper levels to find a seat, which is a little exacerbating and occasionally exasperating‒and I didn’t want to pay to Uber back to the house like I did on Monday and then Thursday for the above reasons, so…I stayed here in the office overnight.

I’m tired of being in pain, I can tell you that.  I wish it were the sort of thing one could simply “get used to”, but biology does not tend to select for creatures that can get used to and ignore pain.  That would defeat the whole usefulness of pain.  Make no mistake:  like fire alarms, pain was and is (and probably always will be) terribly useful.  And “terribly” has more than one legitimate meaning here.

The trouble is that in the modern world, we suffer from and yet survive injuries and disorders that would almost never have been survived by our ancestors, and we can live on with the consequences of these injuries and illnesses for decades, but our nervous systems don’t have any clear function that suppresses or diminishes pain after a while.  There’s no selection pressure favoring such a thing.  Even for our ancestors who might have survived to have chronic pain, that problem tended to develop after peak reproductive years had already passed, and so evolution literally could not and cannot detect the issue.

Indeed, it’s just barely conceivable, though by no means demonstrated, that it might be good for male humans who have injuries that hamper them to feel the pain worsen, to have it lead to them removing themselves from the population in one way or another.  When they can no longer be physical providers, in order to increase the share of resources for their offspring and their other kin, they can kill themselves, directly or indirectly, giving the genes they share with close relatives that harbor that tendency a selective advantage.  This is hypothetical, bordering on speculative, but it might make some sense.

This could also be related to female humans being better suited to endure long-term pain than males, since matrilineal support among human tribes is common***, but that’s getting ever more speculative.

Don’t get me wrong; the ideas are plausible.  But it’s just when one’s ideas are strongly plausible‒but not specifically tested or backed by clear and specific evidence‒that one must be especially harsh and strict with oneself.  It’s comparatively simple, and psychologically rewarding, to come up with plausible and logical hypotheses, but even if one is very smart, most of one’s hypotheses are going to be incorrect.  Whether you’re more Popperian or more Bayesian, the crucial usefulness of testing a hypothesis to try to refute it or to see how your credences shift is inescapable.

This mildly interesting digression doesn’t change the fact that I am in searing pain lately, and it doesn’t seem to diminish much for long.  I’m already prone to dysthymia/chronic depression (veering into the acute stage frequently) and anxiety with at least some obsessive compulsive patterns, all of it occurring in a nervous system that is…atypical from the start.

I hate the world.  I hate my body.  I hate the twisted mockery my life has become.  I hate large parts of my mind (but not all of it).  I hate being around people.  I hate being alone.  I really just ought to stop the whole fucking ride and get off.  I just need to work up the nerve and the commitment.  I’m getting there, believe me.

Anyway, I hope you’re having just a lovely Valentine’s Day.

*And to rhyme all the time is to act like a slime and be covered with grime**.

**I know, none of that makes sense.  It’s not really meant to make sense.  I just accidentally did some internal rhyming in a sentence and that stimulated me to do more of it.

***There are good biological reasons for this as well.  Mothers, and therefore maternal grandmothers, all know whether a child is their child or not, so it’s easier to know that it’s a good idea to spend effort and resources on those descendants.  Males, in general, can not be as certain.

by

There’s hope a great blog’s memory may outlive his life half a year.

Hello and good morning.

First of all, 

Actually, that was second of all, wasn’t it, following my traditional Thursday blog post salutation?  I would almost count that greeting as not being a first thing, however; it is practically automatic, requiring no new knowledge and very little in the way of thought.

Still, there clearly is some caloric expenditure in my nervous system related to doing it, and obviously there are impacts upon the world immediately around me.  And once the post is posted, that impact expands, at least a little.

After a very short while, I suspect, any impact that my writing that particular opening had will be entirely washed out by noise‒even thermal noise at some point.  Like the man said, “The world will little note nor long remember what we say here”.

Of course, the irony is that Lincoln’s speech is what we do remember most from Gettysburg.  By “we”, I mean Americans in general.  I don’t know if anyone in the rest of the world ever reads Lincoln’s Gettysburg Address (though it is a very well written, concise, and moving speech).

And yet, his point is that we ought to remember the battle, and the lives of the soldiers involved in it, and (to my mind) we ought to try to understand the causes of the Civil War and to wonder to what degree the soldiers on each side really were committed to the arguments and ideas supporting their group, or if, deep down, they were just fighting for “our group” against “their group”.*  Yet we most remember, ironically, the words of the man who said that the world would little note nor long remember what he said there.  That was the point I was making.

Anyway, it’s January 1st, the first day of 2026.  Huzzah.  Rah.  Yippee Kiy Yay.

I don’t think it bodes well for the year to start on a Thursday, since this is the day that DentArthurDent had such trouble getting the hang of.  On the other hand, maybe it’s a good thing, since Thursday is and has been my blog day for quite some time, even when I was writing fiction every other weekday.  Probably neither fact matters.

Of course, I am going to work today, despite it being such a universal holiday, and I am not at all happy about it.  I did no celebrating overnight, of course; what on Earth would I celebrate?  But my sleep was not good, anyway, because of all the fireworks and nonsense.  Also, the people with whom I share a house had a big family get together that had barely ended by the time I started writing this.  And, of course, I have chronic insomnia anyway.

It’s actually rather cold here in south Florida‒in the mid-forties right now‒and that makes getting to work slightly less pleasant than usual.  Also, the transit systems are on holiday schedules, and I have a long commute, especially since I have no vehicle.

I also feel that I might be coming down with a cold, but I’m not going to call in sick, because then it would look like I was pretending to be sick so I wouldn’t have to come in on New Year’s Day.  Still, my ears are plugged and my throat is a bit raw, and what might be just my allergies is acting up more than usual.  I’m not really coughing or sneezing, though.  Still, maybe I’ll develop pneumonia and die.  Fingers crossed!

Speaking of ears (I was, you can go back and check), all of a sudden in the middle of the night last night persistent tinnitus began in my left ear.  I have had chronic tinnitus in my right ear for about 18 years now, probably largely due to recurrent ear infections, which have tended to localize to the right side more often than the left.  When you have chronic tinnitus for so long, you get to the point where you…almost…don’t notice it anymore, though I do notice how bad the hearing is in my right ear.

And now my left ear feels very much like the right, with the high, sharp, intense pitch constantly sounding.  Mercifully, it seems to be roughly the same pitch as the noise on the right, a very high D note.  But it is quite annoying, and I fear my hearing is going to be too reduced for me to enjoy music, which is not so much terrifying as horrifying.

Ah, what are you gonna do?  This is life‒it’s a load of crap, but at least you get to die at the end.

I suppose I’ll be writing another post tomorrow, and probably Saturday as well, so you have that (those?) to which to look forward if nothing else.  I don’t know how many people will even read this post today, to be honest.  Will it be fewer than usual?  Will it be more?  Does it matter?

I know the answer to the last question at least.

Again, Happy New Year.  I’ll leave an optimistic-seeming GIF here below for you.  I don’t necessarily share the sentiments, but to be fair, as the Doctor knows full well, great isn’t necessarily good.

TTFN

*I’m reminded of Faramir’s words (in the movie) regarding the fallen soldier on the field:  “The enemy?  His sense of duty was no less than yours, I deem.  You wonder what his name is, where he came from.  And if he was really evil at heart.  What lies or threats led him on this long march from home.  If he would not rather have stayed there in peace.  War will make corpses of us all.”

by

“Though this be madness, yet there is method in’t”

Well, first let me apologize for yesterday’s blog that largely concerned the weather, and in a trivial sense at that.  It was rather lamentable, I know, with emphasis on the first four letters of that adjective.

On the other hand, I don’t apologize for having had my little bit of fun with the date.  That may have been even less interesting to most of you than my jabbering on about the weather, but I like it.  I fully expect that I will do such things again.  For instance, in a similar vein, today is a bit fun because it is 11-12*, so the numbers are in appropriate ordinal sequence with no gaps.

That’s not very fun.  More fun will be had (by me, anyway) on Friday, when it will be 11-14-25.  If you don’t immediately see the fun there, it may help that a similar fun date next month will be available on 12-13-25.  This fun also works with the European date order (but in both you have to leave out the digits that denote the century).  Also, there were no equivalently fun dates in any month before October.

This is the most fun I’ve had on any kind of date in at least 16 years, I would guess.  That’s an easy call, because I haven’t been on any date at all in at least that long.  See what I did there with the multiple meanings of the word “date”?  Of course you did.  What do I think you are, a moron?

No, I do not think that.  You are reading a blog post, so you are a reader, which gives you a serious leg-up, moronia-wise.  You draw from the well of that greatest of all human inventions:  written language.  Your taste in reading material may be somewhat questionable, but I cannot legitimately complain about that.

Wow, I feel like I ought to be almost done with this post, but I’ve barely passed 300 words.

On to other things.  I’m going to try to do a better job about science reading during my downtime in the office.  It’s not that I’m completely slacking; I’m reading Shape by mathematician Jordan Ellenberg, and I just read his earlier book How Not to Be Wrong.  I’ve read both before and/or listened to the audio books, but they are well worth rereading.  He’s a great math professor, and has a gift for explaining potentially abstract concepts.  I think he’s slightly better at this than Steven Strogatz, the author of The Joy of X and Infinite Powers, but they’re all good.

I also just yesterday gave in to an urge I’ve had for some time:  I ordered a textbook I liked in med school but which we didn’t really get into as deeply as I would like:  Principles of Neural Science, by Kandel et al.  The edition I had was by Kandel and Schwartz, if memory serves, but Dr. Schwartz is no longer involved, it seems.

It’s a textbook, so it’s pricey, even in paperback, but I discovered that I could put it on a payment plan through Amazon, so that’s what I did.  It arrives today.

I’ve also resolved, at least tentatively, to try to take the heat off my reading of my science books‒including the above newcomer‒by doing something I did when reviewing/studying in med school:  I would get a text that I was reviewing, and I would pick a section to read/review by flipping a coin.

Actually, it was a series of flips, each one dividing the “remaining” part of the book in half.  In other words, for the first flip, heads would mean I would look in the front half of the book, tails would mean the back half.  Then the next flip would decide to which half of that half I would narrow things down further.

Anyone who has spent any time dealing with computers and/or binary numbers can readily recognize that, with 10 flips of the coin, one could choose a specific page in a 1024 page book.  I guess every flip would count as a kind of “half-life” for the book’s pages.  If one wanted, one could even choose one’s pages not with a coin flip, which is not truly random, but with a quantum event that has a 50-50 chance, like measuring whether a given electron’s spin is up or down.

Of course, I don’t have a Stern-Gerlach gate, so I would have to “farm out” that process.  But I understand that there are apps that you can use that have their sources at labs where each decision is truly made by a quantum measurement.

It’s not terribly practical nor more useful for pickling book pages than is a coin flip, but if you’re a convinced advocate of the Everettian, “many worlds” version of quantum mechanics, it has the added “benefit” that each “flip” will divide the universe into two “worlds”, one where you choose from the earlier half, another where you choose from the latter.

Coin flips do not enact such splitting, not in anything but the trivial sense that every quantum level interaction potentially does so.  The experience will be the same for you, though, except whatever glee you might derive from splitting the universe to choose a section to read.

Anyway, I’ll be trying to read my books, random section by random section.  Believe it or not, this works for me.  I don’t have to learn things in order, usually, and this method avoids me feeling bored while trying to trudge through a text in order.

Perhaps I do have some aspects of ADHD up in there in my brain.

Well, I’ve now passed my target length for this post by some margin, so I’ll call this enough for today.  I expect to be writing another post tomorrow, but like everything else**, it is not absolutely certain.  I hope you have a very good day.

*Only in the American style Month-Day-Year format, though.  It is less fun in the European Day-Month-Year format.

**Yes, even death and taxes, in principle.

by

Celebrate good times? Come ON.

I had a notion this weekend that I would write this blog post on Sunday afternoon/evening and set it up to publish itself‒so to speak‒this morning.  Then, I would use this morning to perhaps review an/or rebegin HELIOS, or maybe to work on Outlaw’s Mind or DFandD.  I even thought I could write any of those‒especially HELIOS‒on my smartphone, since I have them on Google Docs as well as MS Word.

So I thought, anyway.  When I looked, though, I found that I don’t actually appear to have any version of HELIOS on my Google drive, so it must either be on Word or I never typed in the little bit I had of it.  Of course, I could have just decided to restart and bring one of my spiral bound notebooks and write in that.  The only trouble with doing it that way, if I write during my morning commute, is that I eventually have to retype everything into one of my computers or smartphones.

Now, I have never done the thing* of handwriting a first draft and then copying it into a phone, but I have done that with handwriting and computer word processors.  That method has produced some of my best stuff (by some measures), including Mark Red, The Chasm and the Collision, Paradox City, and even part of The Vagabond, though that last one was written mainly on WriteNow on a Mac SE.  So, maybe the handwritten-to-smartphone idea could actually work pretty well, now that I think about it.

Anyway, all that’s fairly moot, because I did not in fact write this blog post on Sunday afternoon nor yet on Sunday evening.  I am writing it, as I usually do, in the morning, in the midst of my commute to the office, which is so effing early, but which is nevertheless far later than when I woke up.

I’m more than a bit disappointed in myself for failing to carry through with that idea, but it’s easy to think of ideas that seem so doable when you first think of them.  And they are doable, of course.  Not only is it physically possible for me to have written this post yesterday evening and to set a precedent of doing the blog posts in the evening and writing fiction in the morning, it’s banal.  If you told someone that had happened, they would be unlikely to do much more than shrug and say something like a noncommittal “cool”, before going on their way.

But as we all know‒or should know‒it’s much easier to intend to do things in the future than it is to muster the motivation to do them in the moment when one was hoping to do them.  There are many shifting, often conflicting, drives in the human** psyche, and our actions are born of a kind of vector sum of all those “forces” in any given moment.

But not only do those forces shift due to things as seemingly mundane as one’s current state of appetite or fatigue, but they are also affected by what one has done immediately before; for the outcome of that vector sum in one instant feeds back on the system in numerous places, changing the sum (I was going to write “changing the calculus” but I thought that might be mathematically confusing and even misleading, since I am not discussing calculus) with every new iteration.  These iterations and changes aren’t quite happening on the scale of the Planck time***, but they happen quickly‒certainly at least at the “speed of thought”, whatever that might be.

Even the physiological, hormonal, energy state of the body from moment to moment changes those vectors, sometimes a great deal.  If you find yourself needing to use the bathroom while you’re trying to accomplish some task, it can certainly change the state of your concentration.  And if you should suddenly begin to have difficulty breathing, it will distract you from pretty much anything else.

That’s why on airplanes they tell you that, in case of cabin depressurization, if you’re traveling with someone who needs help putting on the oxygen mask, put yours on first, before you help your companion.  If you can’t breathe, your ability to help anyone else is going to tank very rapidly.  We can live weeks to months without food, days without water, but only minutes without air.

On a less extreme angle, if one is hypoglycemic (for whatever reason), it strongly affects all the functions of one’s body, particularly one’s neuroendocrine system.  Less extreme but more persistent issues can sabotage one’s focus upon much else.

I don’t need to tell you, probably, that pain makes it much harder to focus and bring effort to bear on other things.  This is one of the most annoying aspects of chronic pain:  one does not quite ever become accustomed to it, because that would miss the whole biological point of pain.  Making pain something you could ignore would be a bit like making a fire alarm that plays soft, easy-listening elevator music at unobtrusive decibel levels.  It would be less annoying, but being burned to death in a fire is a bigger issue, even if it isn’t very likely.

Of course, if your (typical) fire alarm is stuck on, you may not ever be able completely to ignore it.  You also will not know when there is a real fire. Or at least you will be less likely to know.  And since that can potentially be a matter of life and death, the chronic alarm, like chronic pain, is in its own manifold ways life-threatening.

All that is very tangential to my original point, which was that I am writing this blog today, not writing fiction (at least not this morning on my commute).

Oh, well.  If there’s one day I can let myself get away with slacking a bit, I guess it’s today.  I hope you all have a good one.

*How’s that for clever, descriptive writing?

**Or whatever I am.

***Though the processes that underlie them do.

by

Tear down the wall(s)!

I saw a video on YouTube yesterday in which a neuroscientist was being interviewed and asked to “grade” the danger level of various drugs—obviously not all of them since that would have taken far longer than the hour the video lasted.  Mind you, the video ran much more quickly for me, because this is one of those that I watch at 1.5 times speed, which I can get away with if I have the subtitles on and the speaker doesn’t speak too quickly.  I don’t do this for reaction videos or comedy videos, of course, and I certainly don’t do it with music or music reaction videos.  That would be absurd.

Anyway, watching the video, in which the scientist discussed the effects and mechanisms of action of the various drugs, made me think of something that has occurred to me before in recent months and years:  What if someone slipped MDMA (aka Ecstasy) into the food and/or water of all the members of the Senate and House of Representatives* before every legislative session?

This drug has the tendency to lower psychological barriers between people, to encourage a feeling of acceptance and a kind of “unconditional love”, without many other serious untoward effects in most cases (I have never tried it, but I have never tried most non-prescription drugs).  It would be rather interesting to see what legislatures could accomplish if they felt real warmth toward each other rather than seeing each other as opponents and even frank enemies**.  I wonder what might happen.

Alternatively, or similarly, it would be interesting to see a similar experiment involving the UN.  Heck, it would be great just to infuse every water-supply throughout the middle-east with MDMA.  I would not want to use any true hallucinogens in that region of the world, though—we don’t need new religions or spiritual notions popping up in a region that is already the wellspring of the western world’s absurd religious conflicts.

It would be great just to calm the overactive amygdalae of the people in the various legislatures and international organizations, to encourage their prefrontal cortices to be more active, so they can work together for the good of the people they have chosen (and competed) to represent—and whom they fail every time they put partisan hostility above the best interests of the people of the country.  Maybe it would be simpler just to fit all legislators and similar officials with shock collars that activate any time that individual’s voice goes above a certain decibel level, or when a localized EEG detects too much activity in the limbic system and not enough in the frontal lobes.

This is all pipe dreaming, of course, though there’s nothing in the laws of physics that prevents either of these notions from being brought to bear.  Still, it’s probably refreshing to see me thinking of plots and plans intended to work to help people get along better rather than just to obliterate them from the face of the cosmos***.  Though that may well be more likely to happen, considering the warnings of a recent book I just got.

This book is If Anyone Builds It, Everyone Dies, a warning book about the dangers of superintelligent AI, written by one of my favorite thinkers, Eliezer Yudkowsky, and his coauthor, Nate Soares.  They appeared (so to speak) on Sam Harris’s podcast that came out yesterday.  Now, I have not listened to the entire podcast yet, and I certainly haven’t read the book yet, but I have little doubt that the authors are at least not far wrong in their warnings.

I’m not going to go into those arguments now, because you can (and should) read the book or at least look into Eliezer Yudkowsky’s work and ideas.  His book Rationality:  From AI to Zombies is a masterpiece, and though it is long, it is divided into easily ingested chunks, since it started out as a long series of blog posts.

I occasionally toy with the idea of doing podcast type stuff like Sam Harris and so many others—indeed, I have done several of what I call “audio blogs” since I don’t know if they would technically count as podcasts—because people really seem to prefer listening to people talk more than they prefer reading.  This is despite the fact that reading is faster and requires less data to convey the same number of ideas.

I don’t know.  It’s probably better for the world if my thoughts and ideas achieve the least penetration into the zeitgeist as possible.  Still, maybe I’ll embed a few examples of my “audio blogs” here for anyone interested in listening, to see if you think it would be worth it for me to do more.

Please have a good day.

On fatigue, depression, general relativity, and spaceships becoming discoid black holes:

___

Morgoth, Arda, redemption, morality, and blame:

___

The Cosmic Perspective:

*If you live in a country other than the US—as most people do—then substitute your own legislative bodies for these.

**It astonishes me how people in the same legislature, in the same country, see each other as opponents and even as “evil” based almost entirely upon the arbitrary and absurd notion of political party.  It’s ridiculous enough when people arbitrarily choose to be loyal to some specific sports team and then hate other ones based purely on that arbitrary self-identification, but when it involves people who are supposed to be trying to manage the governance of the nation, or state, or county, or what have you, it smacks of a complete lack of seriousness and maturity, of childishness.

***Though I still like my idea of getting someone to engineer the mumps virus to make it more likely to cause orchitis****, especially if it can be encouraged to make males more likely to be sterile.  That way we would decrease the population of those who are prone to avoid vaccinations.  But that’s me in my mad scientist mode.

****Inflammation of the testes, a relatively rare complication of mumps.

by

Mind your vectors and terms of address

I’m writing this on my mini laptop computer again, because even though I find the extra weight of carrying it mildly annoying at the end of the day, at least sometimes the irritation of trying to write using my stupid smartphone is worse.

Although, since those two versions of me exist at different times, it’s hard to weigh their degrees of perceived irritation against each other.  In the morning, if I’m using my thumbs to try to type on a diminutive screen in a fashion that could be easily predicted to lead to some manner of repetitive stress injury, its all too natural for the “me” of that moment to hate the “me” of the previous evening who elected not to bring the laptop computer back with him.

But the “me” of the evening, when faced with the minor extra effort of the mini laptop, can feel very much overwhelmed and exhausted and think that the “me” of the following morning won’t find the process of writing using the smartphone particularly difficult.

The human consciousness clearly doesn’t have one, singular, constant terminal drive or goal as an imagined artificial general intelligence might.  I suppose one might think that the drive “to stay alive” would count as an ironically designated terminal goal, but that’s clearly not an accurate interpretation of the situation.

Not only are some people quite self-destructive and even actively suicidal—which you might credibly dismiss as dysfunction, not the lack of a dedicated system, though I think that would be imprecise—but there’s no good way to think that such a specific drive could evolve.  Evolution is blind to “death” as a concept or force, except as a failure, an accident, a lack, whatever you want to call it.

Before humans, as far as we can tell, no creature on Earth had a concept of “death” as the cessation of the biological processes of an individual organism.  Instead, there are proxies, such as the drive to avoid pain, and the related strong sensation of fear relating to danger and so on.

Similarly, there is no drive “to reproduce” in human (or other animal) minds.  Teens going through puberty don’t start feeling the literal desire to replicate their DNA in other bodies.  Instead, proxies for reproduction evolved, urges and drives that tended to lead to increased chances of reproduction, such as dominance hierarchy drives and displays in social primates such as humans, sexual attraction, and—of course—the pleasure of sex itself, with the reward-based drive to have it as often as feasible (with other inputs adjusting the strength of that drive and causing it to manifest differently in the two biological sexes and at different times and places).

The human brain—like probably all the other adequately complex brains on Earth—is a mélange of modules, with varying drives and processes that have evolved in parallel and sometimes independently, and also developed ways of interacting with each other.  Of course, at the root are the automatic drives that are all but undeniable—the respiratory drive, the thermoregulation drive, and so on.

There are even drives that are neurological in a broad sense, but that are so fundamental that they cannot be interdicted by the rest of the nervous system, only adjusted—I’m thinking here mainly of the heartbeat, the driver of which is in the sino-atrial* node and the Purkinje system of the heart, which is sort of a cross between muscle and nerve tissue.

The upshot is, if you ever feel that you’re “of two minds” on some particular subject, you’re probably not just speaking metaphorically, whether you know it or not.  Your final actions are produced by what I see as the final vector sum (and it can be quite small in the end or it can be huge in magnitude and surprising in direction) of all the drives or “pressures” in the brain that have any effect on decisions about behavior.  Then the action caused by the final behavior feeds back on the system**, changing the lengths and directions of some (perhaps sometimes all) of the contributing vectors, causing changes in the inputs and thus changes in the final vector sum of behavior.  Lather, rinse, repeat as needed, ad nauseam if not actually ad infinitum.

Please don’t imagine this as the sum of physical vectors in real spacetime.  The number of possible dimensions of such mental/neurological vectors is huge.  For all I know, there might even be spinors and tensors and matrices involved, but I don’t think those are necessary for my vague model.  “Simple” higher dimensional vectors probably do the trick.

What a curious set of things about which to write that was!  I had originally intended to start this post with some version of The Simpsons’ “Hi, everybody!”  “Hi, Dr. Nick!” exchanges, perhaps then noting that I could change “Dr. Nick” to “Dr. Robert” and thus reference both The Simpsons and the Beatles at the same time.

But then I might have noted that, although the Beatles song is so titled, “Dr. Robert” is not the way anyone has ever referred to me in actual practice.  It would be, honestly, a little weird for someone to refer to their physician as, for instance, “Dr. Joe” or “Dr. Judy” or whatever, certainly in our culture.

Mind you, there was that tendency for a while (it may still be prevalent) to have kids speak to adults such as teachers and daycare workers and people of that sort using their “title” and then their “given name”, such as “Miss Barbara” or “Mister Jimmy”.  I have always thought that was weird.  I mean, just imagine someone trying to address a certain prominent fictional character as “Dr. Hannibal”.

Alas, that all ended up being a discussion not worth having, except as an afterthought.  Though it’s debatable whether any discussion at all is actually worth having—including the discussion about whether any discussion is worth having.

You all can discuss that if you want; feel free to use the comments below, and to share this post to your social media platforms or what have you.  When you do discuss it, remember to define your terms ahead of time, and stick to them rigorously—i.e., the meaning of “discussion”, and of “worth”, and so on—so that you decrease your chances of getting involved in semantic games and misunderstandings and sophistry.

Whatever you choose to do, please try to have a good day.

*The “sino* in that term relates to its location in what’s called the sinus of the heart, and the “i” in it is a long “i”; it has nothing to do with China, though an identical prefix is sometimes used to mean “related to China”, but in this case with a sort of short “i” sound…or, really, a long “e” sound.

**And there are surely numerous other feedback loops all along the way affecting many, or perhaps all, of the vectors.

by

Lost then found thoughts about lost connections

While I was getting ready to go this morning, I thought about writing this blog post.  I thought about my usual starting point of saying something like, “Well, it’s Wednesday morning again,” or some other such inanity.  But then, as I was thinking about that, another, more interesting beginning and an actual, rather interesting, topic occurred to me.

Then, by the time I got ready to start writing—i.e., now—I had completely forgotten what I meant to write.

That’s terribly frustrating, but it is par for the course.

Oh, wait!  Maybe what I was going to write was about my realization regarding the effects of having a very uncomfortable crisis, but one that is inherently finite*.  It’s probably pretty obvious to you that what made me think of this was my recent adventure with a kidney stone.

Of course, while it was happening, it drowned out everything else, especially in the acute stages.  If that had been something without an endpoint, and if there were not sufficient medication to control the pain, then death would have been the only feasible alternative.  Even later, with the stent in place and the literal, constant, burning feeling that I needed to urinate for two weeks, things were pretty harsh.  But though it did not truly drown out my depression, and it was thoroughly exhausting, it did rather overshadow much of my chronic pain.

The day the stent was taken out I felt a fair amount of relief, of course.  But before long my usual existence asserted itself, with all its emptiness, and of course, with all its chronic pain.  And I remembered that, really, I have nothing going on in my life at all, nothing to which I look forward in any kind of long-term sense, and I have no further clue about or hope for my future.

It’s a bit reminiscent, on a shorter time scale, of what happened when I was a “guest” of the Florida Department of Corrections.  Though I was/am innocent of the charges that were created against me, I took a plea bargain for three years (toward which time served applied) because it was tolerably short and I didn’t want to risk the possibility of the much longer sentence with which the prosecution threatened to try to get, risking the outcome on the potential of a jury of my peers to see past my (apparently) not terribly endearing personality and the simple fact that I was a doctor and thus, to those who might be in a typical jury, a generally hated “elite”**.

I think it was the best available choice at the time.  And while I was “up the road” I was able to console myself with looking forward to seeing my children again once I got out—and to see them before they were adults, which would not have been the case otherwise—and that gave me the optimism to write first Mark Red and then The Chasm and the Collision and then Paradox City while I was at FSP West.

But then, of course, once I got out, it turned out that my kids didn’t really want the discombobulation of me having visitation or anything of that sort.  While I was heartbroken, I didn’t feel that I had a right forcibly to disrupt their lives when I had already fucked everything up, first with my personal health problems, then with my misguided attempts to help other people with chronic pain that led me to be arrested.

So, I bit the bullet and kept on writing at least, on my own, though I think my stories grew steadily bleaker and darker over time.  And I learned to play guitar and wrote and recorded a few songs, and did some covers and everything.  But I still didn’t see my kids, and haven’t even communicated with my son other than to receive his email stating that he didn’t really want to have a relationship with me (“right now”).

At least I got to see my youngest when I was visited in the hospital with my kidney stone.  That was a gift that was well worth even that much pain.  But now I’m back to my nosferatu existence, and like Vermithrax***, though I don’t feel pain as severe as the kidney stone, I still feel constant pain.

There may be people who can have chronic pain without getting depressed about it, and indeed, without losing their zest for life, but I fear I’m only left with the squeezed dry pulp of mine.  It seems to be just the way I’m built neurologically.

I suspect that most people who keep their spirits up despite chronic pain and disability do so because they are surrounded by a local support system of some sort****, and they probably do better at connecting with and getting along with other people than I do.

I’ve only ever really been close to specific, core groups of people, and with ones nearby, that I saw nearly every day.  I’ve never been good at connecting over long distances, and I have a hard time even picturing people when they’re far away.  I mean, I can “picture” them in the sense that I know what they look like, and I will be able to interact with them if and when I see them, but I cannot in any intuitive sense “model” their existence elsewhere.  I cannot really get a feel for what they might be doing and certainly not for what they might be thinking.

When even the people I love are far away from me, they really exist more as concepts than as people whose reality I can feel.  They are missing in a bleak and rather horrible way.  I feel terrible about that fact, and I hope it doesn’t come across as insulting—though it has probably hurt the feelings of people about whom I care on more than one occasion—but it seems to be just the way my brain works.  It’s also probably related to the fact that I never have for an instant imagined wanting to be someone other than myself, even though I hate myself; I just cannot even conceive of what that would mean, let alone wish for it.

Oh well, whatever, never mind.  I’m back on the train, yeah, and here I go again, on my own…alone again, naturally.

(I do like to quote things, don’t I?)

I hope you have a good day.

*Of course, as far as we can tell, pretty much everything is inherently finite, but some things are much more constrained and contained in time than others.

**This is based on what my attorney, and my attorney’s supervisor, said to me.  I don’t think they were trying to be unkind, and though their judgement was and is fallible, it was likely better than mine would have been.

***I know, I’m mixing fantasy metaphors and similes.  That’s okay; I like them.

****And most of them are probably not “ex-cons”.

by

I have not become comfortably numb

     Well, I misjudged things a bit, and though when I wrote my post yesterday I didn’t realize it, I had developed blisters on my feet from my long walking‒especially the right one, on which I had been wearing a spandex brace (prophylactically*‒I hadn’t yet been having any ankle problems, but wanted to avoid them if possible).  So, today, I am not walking, at least not to the train/work.

     I have realized that topical lidocaine creams, such as the max strength versions of “Icy Hot”, dull the irritation of blisters.  That’s nice to know, in a pinch, though I don’t know if it would dull the pain of a pinch; it seems only to work with superficial pain, not deeper pain.  Curiously, it also seems to dull some of the local signs and effects of inflammation (though Ibuprofen contributed to that).  Don’t worry, I’m not expecting to cover up my pain and forget about it.  That doesn’t seem doable.  I’ve tried.

     If I could slather lidocaine all over my body and thus numb all my pain, believe me, I would do it.  But I always hit a wall beyond which the numbing doesn’t reach.  Heck, I’ve had multiple steroid/lidocaine epidural injections and they didn’t seem to do anything to my pain, even temporarily.

     I should probably study up on the nature of congenital insensitivity to pain, just to see if the metabolic pathways involved in the condition shed any light on the sorts of things that might make a person have their pain sense shut off.  Mind you, given the nature of that disorder**, I suspect that its effects come about through some aberrant development of the nervous system, not by the presence (or absence) of some neurotransmitter.

     If memory serves, the saliva of the vampire bat has significant pain-reducing as well as anticoagulant properties.  I’ve heard all my life about people thinking it would be good to investigate as a source of potential powerful analgesics, but nothing has come of it, as far as I’m aware.  It wouldn’t be all that hard to separate out the molecules in vampire bat saliva and examine them and try to replicate them.  Heck, if you can figure out the bat’s biochemical process for making the molecules, you could develop transgenic bacteria that could produce the substance en masse, like how replacement thyroid hormone is made.

     No, either there were unforeseen difficulties with using the vampire bat’s saliva analgesic, or no one was interested in doing the research (which seems unlikely but is not impossible), or “big pharma” has blocked the research because it would interfere with the sales of opioids and NSAIDs and so on (see picture below for an example of such interference).  I would like to think that’s unlikely; after all, there would be tremendous potential for legitimate profit in a revolutionary new pain treatment.

     Still, if it turned out that anyone in a big drug company or companies did block research into such a potential pain killer, then all the people involved would need to be strapped to tables and have all their joints and other “tender areas”, like genitals and nipples and lips and eyes, injected with some combination of‒for instance‒capsaicin and gympie-gympie leaf extract and fire ant venom, with some uric acid crystals*** thrown in for good measure.  Oh, and also they should be given constant, powerful stimulants so that they cannot escape their pain by losing consciousness.

     That’s if I don’t think of anything even better to do to them.

     Obviously, I take pain treatment seriously.  That should come as no surprise, given my personal, decades-long chronic pain and my own having gone to prison for trying (naively) to treat other people’s pain, only to be thrown under the bus by people who were taking advantage of my naïveté.  I have very little patience for those who would interfere with other people reducing their pain and suffering, or who would make light of the suffering of innocent people.

     Mind you, though I think vindictive thoughts and entertain vindictive fantasies, I would probably (like a moron and a sucker) feel pity even for people who had done such horrible deeds, and I would probably end their lives with minimal pain.

     I would not feel bad about that though.  People who willfully engender greater suffering in others for their own short-term (or long-term) profit, whatever form that might take (unless it is truly and honestly and reasonably something they perceive to be an emergency or an absolute survival need) are more than worthy of being erased from existence.  And while it might be reasonable for those who knew them to miss them, they would not deserve to be mourned.

     Look at me, getting all murderously vindictive about purely imaginary people, when there are so many real people who are thoroughly deserving of such animus.  But, anyway, that’s enough of this weird-ass blog post for today.  I’ll let you go to enjoy something more wholesome.  Please have a good day if you’re able.

*I am pleased to note that my right ankle is in no danger of an unwanted pregnancy.

**And yes, it is a disorder, not just a “difference”, because it significantly reduces the survival and thrival of people who have it.

***Look them up; they’re related to gout.

by

It seems appropriate that coughin’ and coffin sound alike.

It’s Monday again, though I know of no one who asked it to be.  I am not going to write much today (I suspect) because I am quite under the weather‒I’ve been dealing with some form of bronchitis that started Friday, and I’m not feeling much better yet, though my oxygen saturation seems good, and I have no fever (but then again, I am always on NSAIDS and acetaminophen, so it’s hard to be sure I haven’t just suppressed a fever).  By rights, I should probably not be going into the office today, but my coworker is out of town until tomorrow, so basically, I’ve got to keep the office running.

I do have masks to wear, and I don’t just mean fun and/or scary ones.  Neither do I refer to “autistic masking” which is what many autistic people do to fit in with other, neurotypical people.  Lord knows I’ve always tried to fit in, and I definitely put on “masks” and tried to shape myself to please those around me.  I feel almost that my autism presented a little more the way it does in girls than in “traditional” autistic boys, at least as discussed by other people with autism.

Anyway, I’m not really doing this blog as a venue via which to discuss ASD.  That must be the case, since I didn’t even consider the possibility before the last few years, and this blog has existed for much longer.  I suppose it might be interesting for someone (but not me!) to look back at my older posts and see if there are any hints about ASD in the way I write or discuss things.  I doubt that I’m interesting enough for anyone ever to do that, though‒I certainly don’t find myself interesting enough.

It may go without saying that I did not play guitar or go for any walks except to the convenience store this weekend.  I was mostly just laying around and trying to rest.  It’s a bit annoying that I still didn’t sleep well, and only stayed asleep for a while under the effects of delta 9 gummies and 2 Benadryl.  I slept a little more than usual, but of course, it’s not really restorative sleep.

I wonder what it is about the autistic brain that leads to the tendency to sleep poorly.  Is it atypia in the hypothalamus, or are the effects on the amygdala leading to hypervigilance which is consistent with my tendency?  I don’t know for sure how well the neuroscience of autism is progressing, but I guess I could get on Google Scholar and/or check the preprint servers.

Anyway, I think I’m pretty much done for right now.  I’m really very tired and worn down.  I guess I’ll be talking to you all tomorrow, though it’s less likely that you’ll be talking to me.  In the meantime, if you’re able, please try to have a good day.