Well, it’s here at last: the final day of June in 2026 AD/CE. You might say it’s the hospice day for the first half of this year. Let us try to make its passing as peaceful and comfortable as we can. I recommend high doses of opioids.
I’m kidding. I don’t actually recommend such a thing unless one is in severe pain that’s simply not responding to anything else, or unless all the other stuff is simply too toxic.
That’s a big part of the conundrum of opioids. All the other types of pain medications‒aspirin, other NSAIDs, acetaminophen, lidocaine injections, steroid injections and so on‒have significant systemic toxicities, even at relatively moderate doses. They affect the stomach, the kidneys, the liver, the local tissues, the endocrine system, etc. Quite often, one cannot adequately control significant pain for long using them without causing actual, serious, perilous damage to some of the most essential parts of the body.
On the other hand, opioids work. They directly hit the pain centers/processors, and they actually can relieve pain, even very severe pain. But they don’t just relieve physical pain.
Somewhat ironically, that’s one of the big drawbacks. Though they do not cause systemic or organ toxicity, and they will not trigger diabetes, and they will not cause you ulcers (though they may well constipate you), they can affect your behavior and even your character. Their relief of psychical pain‒sometimes the only such relief some people have felt in a long, long time‒is like their relief of more visceral pain: it doesn’t actually correct any underlying disorders.
Well, I suppose if the disorder is simply a neurological misfiring such as that which leads to chronic pain, you could say they do at least act on the area that is dysfunctional. But they don’t cure it. They almost never correct even neuropathic pain; they simply squelch the alarm for a bit. And the successful squelching of the alarms tends to require increasing doses, and can lead to dependence and various other issues.
So, there are no very good, relatively simple corrections for significant pain. This is probably not a surprise, if you think about it. In some form, at least, pain is among the oldest things in nature and among the most crucial (ha ha)* functions of nervous systems‒and even things that aren’t quite nervous systems, like the internal communication systems in hydra and jellyfish or the analogous systems of plants.
Living bodies don’t readily give up on pain, and they have good reasons. Pleasure is nice, and is useful, of course, but it’s like having a pretty picture on your wall or having nice, scented candles in your living room or what have you. No matter how pretty your decorations, you want to have your fire alarms in good working order. You want them sensitive enough to go off even in situations without real fires‒the classic case of burnt toast, say‒rather than take the chance that they will not to go off in the case of a real fire. The first error causes annoyance, perhaps requiring you to wave towels at the sensors and open a lot of windows and so on. The second error can lead to your house burning down, perhaps with you in it.
Of course, these weighted preferences are not absolute. If one’s smoke alarms were always going off‒or even going off a significant fraction of the time‒one might very well want to wipe out the whole system, to pull all the plugs, to remove all the batteries, to flip all the breakers to “off”. Or, indeed, one might simply want to abandon the house entirely, if there were no way to get the alarms to shut the f*ck up. One might even be tempted to burn the stupid place down, just as a form of petty revenge against it.
There’s a metaphor in all this, I would imagine. I’ll leave it as an exercise for you to discern it. I won’t say it’s particularly clever, but it’s not terrible, and it works pretty well. Anyway, I’ve dealt with this subject before, many times, I’m sure. It’s fairly tedious, but it does seem to stick in my mind for some inexplicable reason. I don’t, however, know how to solve the associated problems.
Ah, well. There are some things humans aren’t meant to know.
Ha ha ha ha! Sorry, I couldn’t keep a straight “face” while writing something so very stupid. Humans aren’t “meant” to know (or not to know) anything, anymore than any particular foodstuff “belongs” on a pizza. People can try to learn and understand anything, even everything, and ultimately, in the long run, as far as I can tell, the more one knows and understands, the better.
If you want to do your best in a game, you would do well to learn the rules as well as you can. Because, to quote an old car commercial, in real life there is no reset button. You are the avatar and you are the player, and when you get blasted into nothingness by the depredations of the game’s limitless antagonists, then for the character and for the player, the game is done. There is no respawning, there are no experience points, there is no starting again at the last save point.
Game over.
*I say “ha ha” because the word “crucial”, related to the Latin for cross (apparently evolving into its modern usage from a metaphor for arriving at a crossroads), is also related to the word “excruciating” which derives from the Latin use of torturing as if crucifying someone. And that, of course, relates pretty clearly to the topic of pain.



