Biology

by

Songs from a life less interesting*****

In case it wasn’t obvious, I did not go to work yesterday.  I have a head cold of some variety that seemed to begin in the afternoon on Wednesday‒maybe it started sooner than that, I’m not sure.  Anyway, I stayed at the house yesterday, trying to rest.  But I was pretty stuffed up, which I still am, and now my mouth is dry from (apparent) mouth-breathing when I slept.

Sorry, I know this is really dull material.  Such is life, I guess.  Or, at least, such is my life.  I suppose a dull life is better than many of the lives that would make for more interesting reading.  This was a point I first recall encountering in The Hobbit, when Bilbo remarked that his time in Rivendell would make boring reading, though it was wonderful to experience.

I think it is possible to have an exciting or at least interesting life that does not fall prey to the curse of “may you live in interesting times”.  I think it is possible to have a life that most people would find fascinating to hear about, and which is also quite fulfilling to experience.  But it does seem that this is a relatively small subset of available lives.

For the most part, humans seem to prefer stories about harrowing, horrific things.  This is not restricted to fiction, but is also part of why news media tend to focus on the more dire and terrifying news stories.

Of course, there are probably good, sound biological reasons for this.  As a matter of survival, it’s crucial to attend to danger and threat much more so than to pleasant, routine, comfortable things, because those creatures that don’t become extra alert and energetic when danger is present are less likely to leave offspring than are those that respond with arousal*.  So the fact that many of our favorite stories describe horrible things may be analogous to why so many of our snacks are very sweet and/or very salty:  a supranormal stimulus increases engagement powerfully, and can easily become habit-forming.

How in the world did I get on that subject?  I’m not sure.  I guess I could go back and reread this to find out, but I’ll be doing that when I edit it, anyway, so I’m not going to waste my time now.

In other news, I wrote a second verse for my “weekly” song on Wednesday afternoon, and even took a little notebook with me with the song paper in it, so I can continue the process wherever I might be.  Unfortunately, I did not work on it at all yesterday, but then again, I didn’t really work on anything yesterday.  I’ll try to write a chorus and then a third verse today.

I have to remind myself that I’m not trying to produce something superb, even assuming I could do that on command.  I’m just trying to produce something**.  So if it feels a little inane and contrived to me, well, that’s okay.  It’s just got to be some “song”.

I use quotes there because I am really starting with the poem, the lyrics, which is “usually” how I do things.  I don’t know if I’ll be able to do lyrics and music within one week on the same song.  At least so far, that pace doesn’t seem to be in the process of being achieved, though I suppose I might finish the song and come up with a melody over the weekend.  Or maybe what I can do is make songs in a kind of assembly-line style:  lyrics this week, then next week, while coming up with lyrics for another song, do the melody for the first song.

I have heard that most songwriters tend to do melodies first and then come up with lyrics.  That may be a true statistical statement, but I know it’s not the way everyone does it, because at least two of my favorites do otherwise.

We know, of course, that Elton John writes the music after Bernie Taupin writes the lyrics, by their own description of their songwriting process.  And, of course, many operas and musicals start with the libretto***, and the music is written afterward.  And Roger Waters, one of the best lyricists ever****, implies in The Wall that he writes his lyrics as poems, e.g., “I’ve got a little black book with my poems in…”, and also e.g., the scene in the movie where young Pink has his poem book, which contains the lyrics for the song Money, discovered by the oppressive teacher.

So, writing lyrics and then making a melody afterward wouldn’t put me in bad company (though I don’t know how the band Bad Company actually wrote their songs).

Anyway, that’s enough for today.  Batman knows if I was even coherent.  I suppose the editing will make that somewhat clearer, but my mind might be fuzzy enough that I cannot even tell in the immediate editing period.  But you will know.  So, please, have patience with me.

And have a good day and a good weekend, also, if you’re able.

*There’s nothing sexy in this use of the word, just to be clear.  I’m not referring to creatures that get “turned on” by danger and threat; those types of creatures seem less likely to survive than their compatriots, ceteris paribus.

**Not the Beatles song.  I already did a cover of that, anyway.

***Italian for “little book”, in case that wasn’t obvious.

****As evidence:  He wrote almost all of the lyrics for Dark Side of the Moon, Wish You Were Here, Animals, and The Wall.

*****I feel like this could be a good album title.

by

“Wednesday morning, papers didn’t come.  Thursday night, your stockings needed mending*.”

Well, it’s Wednesday, and I’m feeling a bit better than I have so far this week.  Perhaps I really did have a virus of some type that my body has been fighting.  If so, it triggered/worsened symptoms of already existing pathologies in my body—in my back and hips and shoulders and other joints, and so on—in addition to making me feel achy and feverish, though without the actual fever.

I can’t really blame my psychopathology on a virus, unless it’s some form of mental virus**, or more likely some lifelong accumulation thereof.  Such “viruses” are rarely acute and self-limited, though they could be, I suppose.  What, after all, is a momentary fad or brief obsession, perhaps with a song, or the spread of a particularly funny new joke, that goes away before long?

I don’t really think my mental issues are primarily caused by acute memetic infection, if you will.  They started a long time ago.  In any case, my brain is apparently of an atypical type, at least based on my autism diagnosis, and that creates a substrate on which supervening inputs can become prone to cause certain forms of pathology.  Depression and anxiety are two of those things that are very common in those with ASD—significantly more so than in the general population***.  The statistics on autism indicate that suicidal ideation and attempted and successful**** suicide are much more common in people with ASD than in so-called neurotypicals.

I often think of depression—at least in some of its forms—as a sort of weather-pattern in the mind that becomes self-sustaining in the right circumstances, rather like a hurricane or other massive storm system.  One doesn’t find hurricanes in environments that are not conducive to them—Siberia and the like, for instance—but in minds that are the metaphorical equivalent of the tropics, such mental storm systems may be much more common, and sometimes very destructive.

Who knows, maybe ECT treatment for severe and recalcitrant depression is something akin to the (ill-advised) notion of dropping large nukes in the middle of a hurricane to disrupt its pattern.  If hurricanes occasionally had the tendency to obliterate all or even most life on Earth, we might be willing to try something as extreme as dropping nuclear weapons in a developing tropical storm system to disrupt it, if we could find no other solution.

I wonder if even the large storm cells that occur over places like the great plains of North America could be considered something like episodes of depression (the fact that some weather systems are called “depressions” relates to the barometric pressure, and should not be construed as in any way related to psychiatric depression, other than etymologically).  To what would a “super cell” that produces massive tornados be analogous?

Of course, there need be no actual analogy, because the weather concept is a metaphor, really.  But it is not completely a metaphor, so I don’t think it’s too frivolous to push the notion further in order to trigger some thoughts.  Complex systems like the brain and the weather, with internal feedbacks and feedforwards and “feedsidewayses” that can lead to vicious and/or virtuous cycles can have actual attributes in common if looked at in the right way.

It’s a bit akin to how the motion of a pendulum and the oscillation of a circuit and the “probability waves” of quantum mechanics can be described by very similar mathematics.  Also, the relations between pressure, flow, and friction in fluid dynamics with voltage, current, and resistance in electric circuits are almost spookily alike.

This probably demonstrates something rather fundamental in the nature of reality.  Perhaps it’s distantly related to the fact that geometry seems to have a deeper influence on the workings of reality than one might at first think, as evidenced by the ubiquity of Pythagorean relations and the appearance of Pi (π) in often surprising places.

This is all speculative stuff, and I’m not being very rigorous in my thoughts, though I’m trying not to be too frivolous.  But I think this is a good place to wrap up this post for today.  I hope you all are doing well and that you continue to do well, and even better, that you improve at least a little bit, in at least some way, every day.  You might as well.

*Has anyone reading ever actually mended their stockings (or darned their socks, as in another Beatles song, Eleanor Rigby)?  I have mended a sock at least once in my life, and probably more than once, but nowadays socks are so readily available that I tend just to throw them away when a hole develops.  I guess that’s a testament to how “spoiled” we are in the modern world.  Incidentally, I added the Thursday part of Lady Madonna to this quote-based title because I realized that I’m never likely to use it on an actual Thursday blog post, because for those I use mutated quotes from Shakespeare.

**In his classic book The Selfish Gene, Richard Dawkins coined the term “meme” as a replicator of the mind, and it has become a useful scientific term, in addition to being a slightly imprecise shorthand for usually humorous pictures of various kinds shared online.  Such memes can become highly potent self-replicators in various senses, and they can combine in ways that make them more prone to spread, in “meme-plexes” of various kinds.  Some are useful for the organism, and so could be considered beneficial viruses (memetic rather than genetic) while others can become terribly destructive, at least in certain circumstances.  Certainly the mind-virus(es) associated with the Jim Jones cult was/were lethal to most of those who were infected.  Likewise with the Heaven’s Gate viruses.  Some of such comparisons can be a bit glib, but others are robust and can be subject to rigorous study.

***I’m not referring to a prison-based “general population”, though at times the metaphor of modern society as a prison is truly warranted, especially for those of us with atypical brains.

****There are times when I would think of a completed suicide as indeed a thoroughgoing success, i.e., a positive thing overall, but here I’m just using the term “successful” to mean “having completed what was intended, as intended”.

by

Mind your vectors and terms of address

I’m writing this on my mini laptop computer again, because even though I find the extra weight of carrying it mildly annoying at the end of the day, at least sometimes the irritation of trying to write using my stupid smartphone is worse.

Although, since those two versions of me exist at different times, it’s hard to weigh their degrees of perceived irritation against each other.  In the morning, if I’m using my thumbs to try to type on a diminutive screen in a fashion that could be easily predicted to lead to some manner of repetitive stress injury, its all too natural for the “me” of that moment to hate the “me” of the previous evening who elected not to bring the laptop computer back with him.

But the “me” of the evening, when faced with the minor extra effort of the mini laptop, can feel very much overwhelmed and exhausted and think that the “me” of the following morning won’t find the process of writing using the smartphone particularly difficult.

The human consciousness clearly doesn’t have one, singular, constant terminal drive or goal as an imagined artificial general intelligence might.  I suppose one might think that the drive “to stay alive” would count as an ironically designated terminal goal, but that’s clearly not an accurate interpretation of the situation.

Not only are some people quite self-destructive and even actively suicidal—which you might credibly dismiss as dysfunction, not the lack of a dedicated system, though I think that would be imprecise—but there’s no good way to think that such a specific drive could evolve.  Evolution is blind to “death” as a concept or force, except as a failure, an accident, a lack, whatever you want to call it.

Before humans, as far as we can tell, no creature on Earth had a concept of “death” as the cessation of the biological processes of an individual organism.  Instead, there are proxies, such as the drive to avoid pain, and the related strong sensation of fear relating to danger and so on.

Similarly, there is no drive “to reproduce” in human (or other animal) minds.  Teens going through puberty don’t start feeling the literal desire to replicate their DNA in other bodies.  Instead, proxies for reproduction evolved, urges and drives that tended to lead to increased chances of reproduction, such as dominance hierarchy drives and displays in social primates such as humans, sexual attraction, and—of course—the pleasure of sex itself, with the reward-based drive to have it as often as feasible (with other inputs adjusting the strength of that drive and causing it to manifest differently in the two biological sexes and at different times and places).

The human brain—like probably all the other adequately complex brains on Earth—is a mélange of modules, with varying drives and processes that have evolved in parallel and sometimes independently, and also developed ways of interacting with each other.  Of course, at the root are the automatic drives that are all but undeniable—the respiratory drive, the thermoregulation drive, and so on.

There are even drives that are neurological in a broad sense, but that are so fundamental that they cannot be interdicted by the rest of the nervous system, only adjusted—I’m thinking here mainly of the heartbeat, the driver of which is in the sino-atrial* node and the Purkinje system of the heart, which is sort of a cross between muscle and nerve tissue.

The upshot is, if you ever feel that you’re “of two minds” on some particular subject, you’re probably not just speaking metaphorically, whether you know it or not.  Your final actions are produced by what I see as the final vector sum (and it can be quite small in the end or it can be huge in magnitude and surprising in direction) of all the drives or “pressures” in the brain that have any effect on decisions about behavior.  Then the action caused by the final behavior feeds back on the system**, changing the lengths and directions of some (perhaps sometimes all) of the contributing vectors, causing changes in the inputs and thus changes in the final vector sum of behavior.  Lather, rinse, repeat as needed, ad nauseam if not actually ad infinitum.

Please don’t imagine this as the sum of physical vectors in real spacetime.  The number of possible dimensions of such mental/neurological vectors is huge.  For all I know, there might even be spinors and tensors and matrices involved, but I don’t think those are necessary for my vague model.  “Simple” higher dimensional vectors probably do the trick.

What a curious set of things about which to write that was!  I had originally intended to start this post with some version of The Simpsons’ “Hi, everybody!”  “Hi, Dr. Nick!” exchanges, perhaps then noting that I could change “Dr. Nick” to “Dr. Robert” and thus reference both The Simpsons and the Beatles at the same time.

But then I might have noted that, although the Beatles song is so titled, “Dr. Robert” is not the way anyone has ever referred to me in actual practice.  It would be, honestly, a little weird for someone to refer to their physician as, for instance, “Dr. Joe” or “Dr. Judy” or whatever, certainly in our culture.

Mind you, there was that tendency for a while (it may still be prevalent) to have kids speak to adults such as teachers and daycare workers and people of that sort using their “title” and then their “given name”, such as “Miss Barbara” or “Mister Jimmy”.  I have always thought that was weird.  I mean, just imagine someone trying to address a certain prominent fictional character as “Dr. Hannibal”.

Alas, that all ended up being a discussion not worth having, except as an afterthought.  Though it’s debatable whether any discussion at all is actually worth having—including the discussion about whether any discussion is worth having.

You all can discuss that if you want; feel free to use the comments below, and to share this post to your social media platforms or what have you.  When you do discuss it, remember to define your terms ahead of time, and stick to them rigorously—i.e., the meaning of “discussion”, and of “worth”, and so on—so that you decrease your chances of getting involved in semantic games and misunderstandings and sophistry.

Whatever you choose to do, please try to have a good day.

*The “sino* in that term relates to its location in what’s called the sinus of the heart, and the “i” in it is a long “i”; it has nothing to do with China, though an identical prefix is sometimes used to mean “related to China”, but in this case with a sort of short “i” sound…or, really, a long “e” sound.

**And there are surely numerous other feedback loops all along the way affecting many, or perhaps all, of the vectors.

by

O heavy lightness, serious vanity, misshapen chaos of well-seeming blogs

Hello and good morning.  It’s Thursday, of course‒thus the “traditional” opening salutation‒and here I am again, writing another in a line of hundreds of Thursday blog posts.

Have I said all that I could say, already?  Probably not.  The number of possible 800+ word strings of English writing is surely unfathomably vast.  If I were going to try to give some kind of upper boundary, we would consider that there are a few million words in the English language, and I could just try to solve for a few million to the 800th power.  That’s a huge number (104800). But most of those combinations‒all of them, effectively‒would be nonsense.

By “all of them” I mean that, if one applies the constraints of grammar, or even just of making tolerable sense to a potential reader, the number of strings of 800 coherent words is so much smaller than the number of possible strings of 800 words without care for sensibility that, if one were looking at some shape or field that represented the latter, the former would probably be too small to see, given the constraints on the resolving power of visible light.

It’s a bit like the possibilities implicit in DNA.  The human genome is on the order of a billion or so base pairs* long, if memory serves, and each “site” on the genome has 4 possible “letters”.  So, the potential number of sequences of DNA in that genome is on the order of 4 to the billionth power, which would be 2 to the 2 billionth power, which is about 10 to the 600 millionth power (10600,000,000).

That’s a huge number. Remember, a googol is merely 10100, and it is already a number that far exceeds the number of baryons in the (visible) universe (which is on the order of 1080).  And remember how exponentials work:  every time you add 1 to the exponent you multiply by the base number, in this case 10.  So, 10101 is ten times larger than 10100.

As you can see, the number of possible DNA sequences is beyond astronomical, at least unless we get into, say, the measures of entropy represented by an event horizon, as an indicator of the number of possible quantum states it could have “within”.  But distances and times and numbers of particles in the accessible universe are unnoticeably small compared to the number of possible sequences of DNA**.

However, the vast majority of those base-pair combinations would certainly not code for anything that we would consider human, or indeed any other living creature that’s ever existed on Earth.  Most are the analogue of throwing random words together to make a blog post.  They wouldn’t come close to coding for anything that would be a living creature.

Nevertheless, even ruling out all the nonsense, the number of possible viable human genomes is vast.  It may still be larger than the number of particles in the visible universe, but don’t quote me on that‒I haven’t checked those numbers.  In any case, it’s much larger than the number of humans who have ever lived, and probably larger than the number of humans who will ever live even if the species goes on to become cosmically significant.

What this all comes down to, I guess, is that I haven’t come close to writing all the possible blog posts I could write, even ruling out ones that wouldn’t make any sense and even ruling out ones that differ from others only by a word or two.  I guess this blog itself constitutes a case in point.

But boy, it can be a lot of work trying to write something new every day, and even more work trying to write something interesting.  That’s why I don’t bother with the latter criterion; I just write whatever comes out, which is usually something at least mildly interesting to me, and I figure it’ll reach kindred spirits if they happen upon it‒and if such people even exist.

Speaking of kindred spirits, I hope you all have a lovely day.  At least I hope it will be as good as it can possibly be‒which it will, since once it’s happened, it can’t have been otherwise than it was.

TTFN

*In case you don’t recall, DNA is a long chain molecule of polymerized “nitrogenous bases”, adenine, guanine, thymine, and cytosine.  Because each DNA base can pair up only with its complementary base (A with T, G with C) this allows for high fidelity copying, and thus reproduction.

**Now, if the universe is spatially infinite‒which it looks like it is, but may not be‒then of course the number of particles or quantum states or even planets with life would be infinite, and thus larger than any possible finite number, no matter how big you might choose.  Fun things happen when one deals with infinities.

by

That small model of the barren earth which serves as paste and cover to our blogs

Hello and good morning.

Well, I forgot to bring my mini laptop computer back to the house with me last night, so I am writing this post on my smartphone.  At least that should tend to keep the post brief, I guess.

It feels a bit weird not to be discussing my kidney stone, doesn’t it?  Oh, wait, I guess I just brought it up, so to speak, didn’t I?  Although, you don’t want to bring up a kidney stone in any literal way, of course.  But it does seem that mine must have passed, since the symptoms are almost completely resolved.  It feels weird, in a way, to be able to go a long time between trips to the restroom!

There’s still pretty much nothing else going on in my personal news.  No creative endeavors are underway at all.  I thought about asking my boss if he could bring my black Strat back, but I haven’t felt much other than chagrin at the thought.  I imagine it sitting idle by my desk, mocking me with my apparent inability to do anything at all engaging or creative.

I don’t know what to do with what’s left of my life, if anything.  Why would I try to achieve anything of consequence when humans are, overall, so stupidly unable to recognize almost anything sensible about the world and their place in it, such as it is?  They are so small and provincial and tribal‒though perhaps it’s hypocritical of me to characterize them as such when I am expressing general misanthrope toward them, which is a sort of tribalism/xenophobia/prejudice in and of itself.

Still, I wouldn’t say that all human beings are any one thing other than human beings, and that’s just a tautology.  I don’t like to generalize about 8+ billion beings, except in the obvious, trivial ways.  Though humans are, overall, far more alike than they are unalike, there is nevertheless tremendous variation in their specifics*.  No two humans who have ever lived have been exactly the same; even identical twins have different development and local environments that make them diverge, at first subtly, but with growing potential difference, rather like the progression of a chaotic system.

Two first-degree relatives can diverge more, of course, or at least they are more prone to do so.  And two “unrelated”** humans can diverge still more.  Nevertheless, the phase space through which their trajectories may wander, while functionally limitless in certain dimensions, is nevertheless a tiny sliver of the phase space of all mammals, or of all vertebrates, or of all animals, or of all eukaryotes, or of all terrestrial life.  And we don’t even know what other possibilities may be available.

I guess my overall point is that I do not feel like a part of this species, or even of this biosphere.  I feel other.  I do not feel a sense of connection to the people or creatures around me, not in any deep and persistent way.  Maybe I used to feel that; I can’t recall right now.  Maybe I’ve just degenerated over time.

Oh, well.  I guess for the moment I will go through the motions as I have been and try to see if it gets easier.  I don’t expect it will, but I guess it’s technically possible.

TTFN

*Not in the biological sense of the word, though that ends up being a nice coincidence.

**I put the “scare” quotes around the word because of course all humans are related, and not in some absurd, Adam and Eve mythological way.  Indeed, all life on Earth is related‒yes, even octopuses.  It’s very unlikely that a life form that didn’t arise on Earth would be able to digest any form of sustenance here, because biological material, and the enzymes that break it down, are highly specific in their characteristics and interactions***.

***That’s why I currently inhabit this cumbersome, irritating body, despite all its failings****.

****I don’t really think that I’m an extraterrestrial consciousness trapped in a human body, of course.  That’s just a metaphorical way to express how I feel*****.

*****Or is it?

by

A hot and muggy morning blog post*

Okay, well, it’s Wednesday morning, and I didn’t write a blog post yesterday.  I didn’t go to work yesterday, either, because yesterday was my appointment to get the stent taken out of my right ureterovesical junction—you can look that up in case you don’t already know to what I refer.  In any case, my thought process was that, since to get to my appointment on time from the office would have taken most of two hours, I would’ve had to leave work very shortly after it started, and I was not feeling well at all on Monday, nor on Tuesday.

Now, I am pleased to report, the stent came out without much trouble, though it was terribly uncomfortable.  Nevertheless, it is a true relief to have it gone.  Now, without the access “thread” from the stent hanging out, I can actually not feel like I have to use the bathroom constantly.  That’s a tremendous relief.

The urologist recommended that I drink lots of liquid every day from now on, and when I suggested “At least three liters?” he shook his head and pointed up with his thumb The Accountant style, and told me “Four or five at least”.

I’m not going to resist that advice, of course.  I already live in south Florida, and the heat and humidity are ridiculous.  I probably need to drink quite a bit more than even that if I can; the threat of recurrent kidney stones is a powerful one.  What’s worse, my room’s air conditioner is on the fritz, and it has been for some time.  I looked this morning at a little digital thermometer that I have and that I had forgotten for a while, and the temperature in my room was 89.5 degrees Fahrenheit.  This was at four in the morning.

Well, I already have a new, portable air conditioning unit on the way, which should arrive no later than Friday.  I look forward to it because, although I have quite a good and powerful floor fan, that leaves me with more of a tendency to dehydrate because it cools by evaporation.

I know, all this is rather boring.  I apologize.  I never told anyone I have an exciting or interesting life, though it carries its share of intense drama and angst, I guess.  Still, I can write about much more interesting things than would ever happen to me, and I can even give people happy endings to their stories, which is something that is almost certainly not going to happen to me.

Oh, I forgot to mention, I am writing this blog post on my mini laptop computer, as I suggested I might on Monday (I think I suggested it then, but I’m not going to check to be sure—I’ll have put a link to it, so anyone out there who so desires can go check on my behalf).  It’s been just over a month since the last time I wrote on the laptop computer.  It is a pleasant change to be able to write so fluidly, and in a way that feels much more natural and easier.

That being said, I don’t really have much about which to write other than my recent medical issues.  I continue not to write fiction, and I continue not to play music, let alone to compose it, and I continue not to draw or paint, and I haven’t been reading anything educational at all, whether about physics or mathematics or neuroscience or biology more generally.

Maybe I should get Richard Dawkins’s recent work about the genetic book of the dead.  His stuff is usually pretty gripping, and I like biology.  It’s harder to find physics books that I want to read, because much of the popular writing about physics is stuff that I already know, and about which I know more than is usually discussed in popular books.

I guess that’s just the way it goes.  The world wasn’t built for any of us or for all of us.  It just happened, as did our so-called civilization.  That doesn’t mean it’s not worth trying to make it a better situation for as many of us as we can and to try to avoid committing injustice to others.  But that requires reflection and calm assessment, and humans in general are not strongly disposed to such things.

We can only try, I suppose.  Meanwhile, at least try to have a good day.

*By which I mean that the morning is hot and muggy, not that the blog post is hot and muggy.  What would that even mean?

by

How long should one keep smacking the bottom of that bottle?

I made it through Monday again, it seems.  It wasn’t particularly easy.  Starting in the morning, I developed a nasty, unilateral headache that I couldn’t seem to get to go away.  I finally left the office at lunchtime and went back to the house, where I mostly laid around and tried to sedate myself, with some success.

The headache didn’t really start to fade until around midnight, so I didn’t have quite the rest I might have desired, but at least I got some rest.  And now, only a faint residue of the headache remains.

It didn’t feel like a typical migraine, which I have from time to time‒thankfully not very often‒but almost more like a bad, unilateral sinus headache.  Hopefully, it has pretty much run its course now.

It might be nice if there could be a situation in which one could go through some period of painful illness, but then come out afterwards with one’s prior, chronic pain somehow eliminated.  Of course, that’s not likely to happen in real life.  It certainly hasn’t happened to me.

It is true, apparently, that a bad measles infection can effectively wipe out prior immunities, making one vulnerable to diseases to which one had previous resistance.  I suppose that might even be a boon in someone with an autoimmune dysfunction, though it would be difficult to time the infection just right.

I’m not aware of anyone having tried such a therapy, and I don’t think it’s something I would recommend, even if it were workable (which it really isn’t).  Better just to keep vaccination for measles and other preventable illnesses going and look for other avenues to treat autoimmune disorders.

As for what else to discuss…I’m coming up empty here at the moment.  Actually, it’s not just at the moment, is it?  I’ve been squeezing the dregs out of the mustard bottle that is my life force for a long time now.

Sorry, I know that’s a terrible metaphor, but I don’t feel that I’m really worthy of anything fancier.  Anyway, I’ve certainly spread that condiment out over a lot of sandwiches (that’s my continuing the rotten metaphor, with a sandwich representing a day).  But there’s hardly anything left in there, and there are no refills available, as far as I know, and now I’m really just going through the motions.  There’s just a dribbly little, watery remnant, with no flavor left and very little color.

I really pushed that one to the crumpling point, I fear.  But I hope I at least got my point across.  If I didn’t, that would be a real shame.  What a thing not only to have used a truly lame metaphor but to have it fail to do what one intended.  What a tragic joke that would be.

It wouldn’t be very tragic, of course‒it’s hardly anything of consequence.  But still, it would be sad.

I’m really tired and wiped out, even though I went back to the house early yesterday.  Well, I mean, I did just say that my headache didn’t really start to go away until about midnight, and as per my usual self, I was awake today well before three in the morning.

I know, I know, this is all so boring and repetitive!  I’m very sorry.  I wish I could be telling you all about a new story I’m writing, or about my return to a past story, or about some new music I was learning or writing, or even some new drawings I might have done.

Heck, I’d like to tell you I was making progress in studying quantum mechanics and general relativity or differential geometry or computer programming and computer science in general.  I wish I could tell you (and do so honestly) that I was learning more Japanese, or refreshing my Spanish or learning Russian or German, or even French, all of which languages are interesting.

But I’m not doing any of those things.  I’m not doing anything creative or productive or even just distractive (that’s probably not a formally recognized word, but maybe it is).  I don’t have the energy to do anything creative other than this, if this even counts.

Of course, I go to work and do my job, and that’s all well and good as far as it goes, since I don’t like being a burden to people.  But that’s as good as it gets, I think.

I don’t know what else I can do.  I’m just a mess.  I feel like a tattered and smeared old wrapper from a cheap, fast food hamburger.  I suppose some of the smeared matter on the wrapper might be mustard, if we want to keep the metaphor‒or simile, in this case‒consistent.

Well, my train will be here soon, so I’ll bring this to a close.  I hope I haven’t been too much of a downer.  If I have, well, take comfort in the fact that you are only reading these thoughts.  You don’t actually have to experience them.

Please try to have a good day, and try to have better thoughts than mine.

by

I have not become comfortably numb

     Well, I misjudged things a bit, and though when I wrote my post yesterday I didn’t realize it, I had developed blisters on my feet from my long walking‒especially the right one, on which I had been wearing a spandex brace (prophylactically*‒I hadn’t yet been having any ankle problems, but wanted to avoid them if possible).  So, today, I am not walking, at least not to the train/work.

     I have realized that topical lidocaine creams, such as the max strength versions of “Icy Hot”, dull the irritation of blisters.  That’s nice to know, in a pinch, though I don’t know if it would dull the pain of a pinch; it seems only to work with superficial pain, not deeper pain.  Curiously, it also seems to dull some of the local signs and effects of inflammation (though Ibuprofen contributed to that).  Don’t worry, I’m not expecting to cover up my pain and forget about it.  That doesn’t seem doable.  I’ve tried.

     If I could slather lidocaine all over my body and thus numb all my pain, believe me, I would do it.  But I always hit a wall beyond which the numbing doesn’t reach.  Heck, I’ve had multiple steroid/lidocaine epidural injections and they didn’t seem to do anything to my pain, even temporarily.

     I should probably study up on the nature of congenital insensitivity to pain, just to see if the metabolic pathways involved in the condition shed any light on the sorts of things that might make a person have their pain sense shut off.  Mind you, given the nature of that disorder**, I suspect that its effects come about through some aberrant development of the nervous system, not by the presence (or absence) of some neurotransmitter.

     If memory serves, the saliva of the vampire bat has significant pain-reducing as well as anticoagulant properties.  I’ve heard all my life about people thinking it would be good to investigate as a source of potential powerful analgesics, but nothing has come of it, as far as I’m aware.  It wouldn’t be all that hard to separate out the molecules in vampire bat saliva and examine them and try to replicate them.  Heck, if you can figure out the bat’s biochemical process for making the molecules, you could develop transgenic bacteria that could produce the substance en masse, like how replacement thyroid hormone is made.

     No, either there were unforeseen difficulties with using the vampire bat’s saliva analgesic, or no one was interested in doing the research (which seems unlikely but is not impossible), or “big pharma” has blocked the research because it would interfere with the sales of opioids and NSAIDs and so on (see picture below for an example of such interference).  I would like to think that’s unlikely; after all, there would be tremendous potential for legitimate profit in a revolutionary new pain treatment.

     Still, if it turned out that anyone in a big drug company or companies did block research into such a potential pain killer, then all the people involved would need to be strapped to tables and have all their joints and other “tender areas”, like genitals and nipples and lips and eyes, injected with some combination of‒for instance‒capsaicin and gympie-gympie leaf extract and fire ant venom, with some uric acid crystals*** thrown in for good measure.  Oh, and also they should be given constant, powerful stimulants so that they cannot escape their pain by losing consciousness.

     That’s if I don’t think of anything even better to do to them.

     Obviously, I take pain treatment seriously.  That should come as no surprise, given my personal, decades-long chronic pain and my own having gone to prison for trying (naively) to treat other people’s pain, only to be thrown under the bus by people who were taking advantage of my naïveté.  I have very little patience for those who would interfere with other people reducing their pain and suffering, or who would make light of the suffering of innocent people.

     Mind you, though I think vindictive thoughts and entertain vindictive fantasies, I would probably (like a moron and a sucker) feel pity even for people who had done such horrible deeds, and I would probably end their lives with minimal pain.

     I would not feel bad about that though.  People who willfully engender greater suffering in others for their own short-term (or long-term) profit, whatever form that might take (unless it is truly and honestly and reasonably something they perceive to be an emergency or an absolute survival need) are more than worthy of being erased from existence.  And while it might be reasonable for those who knew them to miss them, they would not deserve to be mourned.

     Look at me, getting all murderously vindictive about purely imaginary people, when there are so many real people who are thoroughly deserving of such animus.  But, anyway, that’s enough of this weird-ass blog post for today.  I’ll let you go to enjoy something more wholesome.  Please have a good day if you’re able.

*I am pleased to note that my right ankle is in no danger of an unwanted pregnancy.

**And yes, it is a disorder, not just a “difference”, because it significantly reduces the survival and thrival of people who have it.

***Look them up; they’re related to gout.

by

Udaimonic so-and-so, U.

It’s the last day of February, everyone.  It’s also Friday, the last day of the “typical” work week, and it is also the last day of my work week, since I am not working tomorrow.  It’s not as though I have anything particular to which to look forward this weekend, but I do need the rest.  I’ve been feeling exceptionally exhausted lately.

Alas, as you know, exhaustion does not translate into sleepiness for me, just weariness.  Somewhere in the neurologic centers and relays that connect such things as fatigue and sleep, I have a short circuit, or at least one that doesn’t perform up to spec.

Of course, my pain continues, though as always, I have tried to adapt my activity, my posture, my exercise, my shoes…even my underclothes to try to decrease my pain.  I have put a tremendous amount of mental energy into this over the years.  If I had devoted that time/energy/effort to the study of any abstract problem‒say, the dynamics of an accelerating near-light-speed spacecraft approaching its local Schwarzschild “radius” as length contraction and “relativistic mass” take effect and bring GR into play‒then I would have made significant, possibly really important, advances.

Alas, when one’s problem is chronic pain (coupled, causally or otherwise, with insomnia), it is very difficult to focus enough mental acuity upon other things.  The very nature of pain as a neurological process in animal systems does not allow it to be easily ignored, or indeed to be ignored at all for any length of time.

Those creatures which can readily ignore pain for long, or who don’t experience pain*, don’t tend to leave as many offspring as those for whom pain is both present and urgent.

It’s a similar problem for those rare people who don’t experience fear, though clinically this seems more likely to happen as a result of damage to the brain rather than being congenital, possibly because children without fear really don’t tend to reach adulthood.

It’s interesting to note that, anecdotally at least, people who don’t feel fear tend to be quite frightening to would-be bullies and predators.  They don’t behave like others do in response to potential threats, and predators tend to rely on fear in others.  A person who looks at them with no more fear than they would at a tree or a rock can be quite disconcerting for someone who has become dependent upon the fear of others.

This is one of the reasons it can be good to have dogs present if you’re guarding something.  They don’t fear guns (generally) so one can’t exactly threaten them with firearms.  And if they attack, they don’t hold back.

That was quite a series of little tangents, wasn’t it?  I think they were interesting, but then again, I was the one who brought them up, so that shouldn’t be surprising.  Whether or not anyone else is interested is difficult to guess.  It’s rather akin to the way things are with humor‒it can be very hard to know consistently what other people will find funny, or for them to know what you find funny, so you might as well amuse yourself.  Then, at least, you can watch to see who enjoys your humor, and those people are the ones with whom you can enjoy such things in the future, at least in principle.

I am horribly tired, and I’m in a great deal of pain as I write this, though for the moment at least I don’t notice any fear that might be present.  Time’s been my way when I’ve been so tired and depressed and in pain that I had no reaction to and felt no fear toward things that would normally have made me quite afraid, from minor things like wasps and bees all the way up to oncoming cars and trucks.  I don’t tend to be afraid of people much, never have been‒at least, I’m not afraid of them physically.  Socially, they can make me quite tense.  In that case, though, the tension is not the same as fear, though I guess it qualifies as anxiety.

Speaking of fear, I fear this is it for this week.  I truly hope that you all have a wonderful day and a wonderful weekend and that you are healthy and safe and eudaimonic**.

*There are people who have a genetic disorder called CIPA:  congenital insensitivity to pain with anhidrosis (i.e., they don’t sweat), and they basically don’t experience pain.  They also don’t live very long, and before they die their bodies tend to be quite damaged, often by such simple things as standing in one position for too long, since it doesn’t feel uncomfortable to do so for them.  They also don’t notice infections, and they don’t tend to get fevers.  It occurs to me, however, that though their lives are short, people with CIPA might well have significantly longer pain-free lifespans than, say, I have had.  I had pain issues starting at a pretty young age, after all.  Still, if I could be cured of all pain at this stage of my life, when I am hardly worried about my longevity anyway, I think it would be worth it.

**It’s interesting to consider the prefixes “eu” and “u” in words of Greek origin.  “Utopia”, for instance, literally means “no place”, making it clear that an imagined perfect society does not exist and may be impossible.  Whereas, if one were to write “Eutopia”, one would mean “true place” or “good place”.  Thus, my middle name “Eugene” means “true born” and is etymologically related to the term “eugenics”.  Mind you, only a fool would believe that I was actually the product of some eugenics program, that I am some true-life Khan Noonien Singh***.  “Eugene” was just my paternal grandfather’s name.  On the other hand, while eudaimonia means “good spirit” and refers to a state of general emotional and mental well-being, “udaimonia” would mean “no spirit”.  That sounds more pertinent to me, don’t you think? 

***Though I suppose one could speculate that I was a failure of such a program.

by

And I looked, and behold a pale cat

Well, I have some relatively good news, which is why I decided to write a post today instead of just leaving it:  Dorian, the light gray cat, has returned.  Well…he was back last night, at least, though this morning he was nowhere to be seen once again, which is itself somewhat unusual.

He was a bit scraggly, with some traces of dried blood around his fur on the side of his head and neck, but it didn’t look like it was his blood.  He actually looked lean and healthy, moving very much like the hard-ass stray cat that he is.

I’m guessing that he got into a pretty big fight at some point‒he seems prone to them‒and then hid away somewhere while he recovered his strength.  Then, that pale grey shadow took a new shape* and grew again.

I think stray cats, like defective and damaged people, don’t like to show any weakness to those around them.  Perhaps it’s more accurate to say that they are unable to show their weakness, even though they may crave acceptance and support.  There are good, sound biological motivations for this in stray cats and other mammals; showing weakness or injury can invite further aggression from other cats and even encourage predators.

Of course, human males (or anthropoid creatures living among humans, such as I) are no exceptions to that tendency.

It’s also been said that, in many ways, people on the autism spectrum are like cats, at least in some ways, and I can see the point, though it is an oversimplification.  Still, it leads me to speculate that, sometime in the relatively deep past, perhaps two separate subspecies of humans (maybe the legendary Neanderthals and Cro-Magnons) existed, one being more naturally ultrasocial, the other more constrained but with other capacities that aided their survival.  We know that Neanderthals, for instance, had bigger brains than so-called modern humans, but the structure appears to have been slightly different.

Perhaps it’s the genes from such a separate subspecies that led to some people having ASD or other versions of “neurodivergence”.  To be clear, I don’t know that there’s any good evidence that this is the case.  I did encounter at least one study that looked for markers known to be associated with the autism spectrum and the DNA residua of Neanderthals present in people of European descent.  There seemed to be some correlation, but I didn’t think it was particularly impressive.  So there’s not a lot of data to support the hypothesis.

It would be nice‒in some ways‒to think of oneself as just a different kind of human, not as something alien.  But I think that’s probably a silly dream for me.  I do not belong here in any serious sense; I am an alien, a mutant, a replicant, a stranger.  And to humans, of course, a stranger is presumptively an enemy unless and until proven otherwise.

Anyway, Dorian was back last night, but gone again this morning.  We’ll see if he returns.  There are other cats who come around.  But, of course, there is no real affection from most of them.  They come to me opportunistically, because I put food out for them.  I am useful to them.  Similarly, I am often useful to humans in the world.  I have many skills and abilities, so I have frequently found that people like to have me around to help them get things done.  But eventually, the negatives of my presence outweigh the positives, and people go away (or send me away).

I don’t blame them.  I want to go away from myself, though I have never had any desire to be anyone else.  I would prefer oblivion.  Or maybe I would just prefer rest.

Speaking thereof, I slept almost four hours last night, and of course, I awakened and couldn’t go back to sleep in the wee hours of the night, and I am now at the office finishing this post.  I don’t look forward to the weekend‒there’s nothing good about it‒but at least I can collapse and try to recuperate.  I don’t know if I’ll write anything next week, or just leave everything be.

I feel perched on the borderland between life and death, and the Undiscovered Country beckons.  It must be really great there, because no one who goes ever comes back.

*To be honest, it’s pretty much exactly the same as the old shape.